Cordero, Juan
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Wageningen University & Research
Sammanfattning
Natural antibodies (NAb) are produced without any antigenic stimulation as a part of the innate immune system and provide a first line of defense against pathogens. Hence, they may be a useful trait when estimating an animal's potential immune competence and in selection for disease resistance. The aim of this study was to identify genomic regions associated with different NAb traits in milk and potentially describe candidate genes. Milk samples from 1,695 first-lactation Holstein Friesian cows with titer measurements for keyhole limpet hemocyanin, lipopolysaccharide, lipoteichoic acid, and peptidoglycan-binding total NAb and isotypes IgG(1), IgM, and IgA were used. Genome-wide association study analyses were performed using imputed 777K SNP genotypes, accounting for relationships using pedigree information. Functional enrichment analysis was performed on the significantly associated genomic regions to look for candidate genes. For IgM NAb, significant associations (false discovery rate
Nyckelord
natural antibody; dairy cattle; genome-wide association study; immunoglobulin
Publicerad i
Journal of Dairy Science
2019, volym: 102, nummer: 12, sidor: 11092-11103
SLU författare
de Koning, Dirk-Jan
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Husdjursvetenskap
Publikationens identifierare
- DOI: https://doi.org/10.3168/jds.2019-16627
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/101799