Reviewing findings on the polypeptide sequence of the SARS-CoV-2 S-protein to discuss the origins of the virus

Sammanfattning

Several investigations suggested origins of SARS-CoV-2 from the recombination of coronaviruses of various animals, including the bat Rhinolophus affinis and the pangolin Manis javanica, despite the processes describing the adaptation from a reservoir of animals to human are still debated. In this perspective, I will remark two main inconsistencies on the origins of SARS-CoV-2: polypeptide sequence alignment of the S-proteins does not return the expected identity of the receptor-binding motif among most of pangolin-CoVs and SARS-CoV-2; accurate referencing for samplings and sequencing deposition of the ancestral bat coronavirus named RaTG13 was missing since the first reports on the SARS-CoV-2 coronavirus. This contribution aims to stimulate discussion about the origins of SARS-CoV-2 and considers other intermediate hosts as a reservoir for coronavirus.

Nyckelord

coronavirus; polypeptide sequence alignment; RaTG13; receptor-binding motif; S-protein; SARS-CoV-2

Publicerad i

Future Virology
2022, volym: 17, nummer: 6, sidor: 393-402
Utgivare: FUTURE MEDICINE LTD

SLU författare

• Cattaneo, Alberto Maria

  • Institutionen för växtskyddsbiologi, Sveriges lantbruksuniversitet
    
  • Université de Lausanne

UKÄ forskningsämne

Mikrobiologi inom det medicinska området

Publikationens identifierare

• DOI: https://doi.org/10.2217/fvl-2021-0233

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/116725