Resolution enhancement of NMR by decoupling with the low-rank Hankel model

Sammanfattning

Nuclear magnetic resonance (NMR) spectroscopy has become a formidable tool for biochemistry and medicine. Although J-coupling carries essential structural information it may also limit the spectral resolution. Homonuclear decoupling remains a challenging problem. In this work, we introduce a new approach that uses a specific coupling value as prior knowledge, and the Hankel property of the exponential NMR signal to achieve broadband heteronuclear decoupling using the low-rank method. Our results on synthetic and realistic HMQC spectra demonstrate that the proposed method not only effectively enhances resolution by decoupling, but also maintains sensitivity and suppresses spectral artefacts. The approach can be combined with non-uniform sampling, which means that the resolution can be further improved without any extra acquisition time.

Publicerad i

Chemical Communications
2023, volym: 59, nummer: 36, sidor: 5475–5478
Utgivare: ROYAL SOC CHEMISTRY

SLU författare

• Agback, Tatiana

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

• Agback, Peter

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Biokemi och molekylärbiologi

Publikationens identifierare

• DOI: https://doi.org/10.1039/d2cc06682c

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/122134