Plant Gel-Mediated Synthesis of Gold-Coated Nanoceria Using Ferula gummosa: Characterization and Estimation of Its Cellular Toxicity toward Breast Cancer Cell Lines

Mousavi-Kouhi, Seyed Mousa; Beyk-Khormizi, Abdollah; Amiri, Mohammad Sadegh; Mashreghi, Mohammad; Hashemzadeh, Alireza; Mohammadzadeh, Vahideh; Alavi, Fariba; Mottaghipisheh, Javad; Ardakani, Mohammad Reza Sarafraz; Yazdi, Mohammad Ehsan Taghavizadeh

doi:10.3390/jfb14070332

Forskningsartikel2023Vetenskapligt granskadÖppen tillgång

Plant Gel-Mediated Synthesis of Gold-Coated Nanoceria Using Ferula gummosa: Characterization and Estimation of Its Cellular Toxicity toward Breast Cancer Cell Lines

Mousavi-Kouhi, Seyed Mousa; Beyk-Khormizi, Abdollah; Amiri, Mohammad Sadegh; Mashreghi, Mohammad; Hashemzadeh, Alireza; Mohammadzadeh, Vahideh; Alavi, Fariba; Mottaghipisheh, Javad; Ardakani, Mohammad Reza Sarafraz; Yazdi, Mohammad Ehsan Taghavizadeh

Sammanfattning

In this study, a novel method using Ferula gummosa gums as a capping agent was used to synthesize the nanoceria for the first time. The method was economical and performed at room temperature. Furthermore, it was coated with gold (Au/nanoceria) and fully characterized using X-ray powder diffraction (XRD), field emission scanning electron microscopy with energy-dispersive X-ray spectroscopy (FESEM-EDX), Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and zeta potential (& zeta; potential). The crystallite size obtained from the results was 28.09 nm for Au/nanoceria. The energy-dispersive X-ray spectroscopy (EDX) analysis of Au/nanoceria revealed the compositional constituents of the product, which display the purity of the Au/nanoceria. The cell toxicity properties of the non-doped and Au-coated nanoceria were identified by a MTT analysis on a breast cancer cell line (MCF7). Additionally, human foreskin fibroblast cells (HFF) were used as a normal cell line. The cytotoxicity results indicated that the toxicological effect of Au/nanoceria on cancer cells was significant while having little toxic effect on normal cells. The toxicity effect of nanoceria clearly shows the dependence on dose and time, so, with increasing the dose of Au/nanoceria, the death of cancer cells also increases.

Nyckelord

Ferula; gold coating; nanoceria; green synthesis; cell toxicity

Publicerad i

Journal of Functional Biomaterials
2023, volym: 14, nummer: 7, artikelnummer: 332
Utgivare: MDPI

SLU författare

Mottaghipisheh, Javad
- Institutionen för vatten och miljö, Sveriges lantbruksuniversitet

Globala målen (SDG)

SDG3 God hälsa och välbefinnande

UKÄ forskningsämne

Biomaterialvetenskap

Publikationens identifierare

DOI: https://doi.org/10.3390/jfb14070332

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/123491