Tamoxifen induces biochemical responses in Pacific oysters Magallana gigas (Thunberg, 1793) at environmentally relevant concentrations

Abstract

The activities of catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PDH), and glutathione-S-transferase (GST) were evaluated in the gills (GI) and digestive gland (DG) of Magallana gigas oysters exposed to tamoxifen (TAM) at environmental concentrations of 10 and 100 ng L- 1 for 1 and 4 days. A higher CAT activity in the GI and DG and higher GPx activity only in the DG was observed of oysters exposed to both concentrations after 1 day. Furthermore, a significant increase in GR and G6PDH, was detected in the DG after 1 day of exposure to 10 ng L- 1 and only G6PDH activity increase after 1 day of exposure to 10 ng L- 1 in the GI. This suggests that the DG is a tissue more sensitive to TAM exposure and was confirmed with the individual Integrated Biomarker Response version 2 index (IBRv2i), highlighting the acute stress caused by TAM and a cellular adaptation.

Keywords

Crassostrea gigas; Bivalve; Antioxidant defense; Emergent contaminant; Mariculture

Published in

Marine Pollution Bulletin
2024, volume: 206, article number: 116696
Publisher: PERGAMON-ELSEVIER SCIENCE LTD

SLU Authors

• Bohn Pessatti, Tomas

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Environmental Sciences

Publication identifier

• DOI: https://doi.org/10.1016/j.marpolbul.2024.116696

Permanent link to this page (URI)

https://res.slu.se/id/publ/131552