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Konferensartikel2022Vetenskapligt granskadÖppen tillgång

Host variation in susceptibility to lumpy skin disease: gene expression analyses of experimentally infected cows

Van Borm, S.; Klingström, T.; Niazi, A.; et al.

Sammanfattning

Lumpy Skin Disease (LSD) is becoming a global threat to cattle and related species. It requires annual vaccination to prevent further outbreaks. There is host variation in the response to infection both in field studies and under carefully controlled artificial infections. Here, we study the gene expression response in whole blood at four time points before and after experimental infection with LSD virus in five cows with divergent disease outcomes. Differentially expressed genes (FDR<0.05) were identified for comparisons between LSD symptomatic and asymptomatic animals at all time points as well as between time points for symptomatic animals. Gene set enrichment showed a role of oxidative phosphorylation as well as a range of disease pathways. While preliminary, these results are the first ever study of host transcriptomes related to LSD.

Publicerad i

Titel: Proceedings of the12th World Congress on Genetics applied to Livestock Production (WCGALP) : Technical and species orientated innovations in animal breeding,and contribution of genetics to solving societal challenges
Utgivare: Wageningen Academic Publishers

Konferens

12th World Congress on Genetics Applied to Livestock Production (WCGALP), 2022-07-03, Wageningen, The Netherlands

SLU författare

Globala målen (SDG)

SDG2 Ingen hunger
SDG3 God hälsa och välbefinnande

UKÄ forskningsämne

Genetik och förädling
Husdjursvetenskap
Bioinformatik och systembiologi

Publikationens identifierare

  • DOI: https://doi.org/10.3920/978-90-8686-940-4_154
  • eISBN: 978-90-8686-940-4

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/132638