Bettembourg, Vanessa
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Abstract
Objective To measure the bioavailability, maximal plasma concentration (C-max) and half-life (t(1/2)) of fentanyl in rabbits after intravenous (IV) and subcutaneous (SC) administration. Secondary aims were to investigate behavioural effects and faeces production. Study design Randomized, experimental, crossover study. Animals A group of six male New Zealand White rabbits, Crl:KBL(NZW), aged 5-6 months and weighing 2.9-3.7 kg. Methods Fentanyl 15 mu g kg(-1) was administered IV and SC to rabbits with a 14 day washout period. Plasma was sampled at 2 (IV), 5, 10, 15, 30, 60, 90, 120 (IV + SC), 300 (SC) and 390 (SC) minutes and analysed by liquid chromatography-mass spectrometry. Sedation was scored from 0-3, 3 being most sedated, 10 and 45 minutes after administration by an assessor blinded to treatment. Oxygen was supplemented if the haemoglobin oxygen saturation (SpO(2)) was
Keywords
analgesia; bioavailability; plasma concentrations; veterinary anaesthesia
Published in
Veterinary Anaesthesia and Analgesia
2026, volume: 53, number: 1, article number: 101159
SLU Authors
Olsén, Lena
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Rydén, Anneli
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Brock von Rein, Josefin
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Gumpert Herlofson, Erica
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Erkas, Malin
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Hedenqvist, Patricia
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Clinical Science
Publication identifier
- DOI: https://doi.org/10.1016/j.vaa.2025.11.003
Permanent link to this page (URI)
https://res.slu.se/id/publ/145608