A neurologic syndrome in golden retrievers presenting as a sensory ataxic neuropathy

Sammanfattning

Background: A sensory ataxic neuropathy has been observed in Swedish Golden Retrievers recently. Animals: Twenty-one affected Golden Retrievers. Methods: Clinical and neurologic status, electrophysiologic, and pathologic status as well as pedigree analyses were evaluated. Results: Clinical signs had an insidious onset between 2 and 8 months of age and a slowly progressive course. Affected dogs were ataxic and dysmetric. They had abnormal postural reactions and decreased spinal reflexes but no apparent muscle atrophy. Clinical pathology, radiography, and electrophysiology of motor systems were all within reference values. Sensory nerve conduction results of affected dogs were significantly different from those of a group of control dogs. Necropsy revealed a chronic progressive central and peripheral sensorimotor axonopathy; the proprioceptive pathways were most severely affected. Conclusions and Clinical Importance: This disease in these Golden Retrievers is distinct from other canine breed-related neurodegenerative diseases or hereditary neurodegenerative diseases described in humans. Pedigree analyses indicated a hereditary background, but the mode of inheritance could not be established

Publicerad i

Journal of Veterinary Internal Medicine
2007, volym: 21, nummer: 6, sidor: 1307-1315
Utgivare: BLACKWELL PUBLISHING

SLU författare

• Hultin Jäderlund, Karin

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Malm, Sofia

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Hedhammar, Åke

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Husdjursvetenskap
Veterinärmedicin

Publikationens identifierare

• DOI: https://doi.org/10.1892/07-005.1

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/15924