Verrucine F, a quinazoline from Penicillium verrucosum

Sammanfattning

Verrucine F (3), a quinazoline similar to verrucines A (1) and B (2), contains one anthranilic acid residue, one L-glutamine residue, and one alpha,beta-unsaturated phenylalanine residue, as determined by NMR, MS, and chemical methods. Compounds I and 3, but not 2, were produced by Penicillium verrucosum J255 and eight additional P. verrucosum strains. Verrucines were typically more concentrated in the inner (older) parts of the colony, and 3 peaked 4-8 days after 1, but at 10-fold lower concentrations (similar to 200 mu g/g). Verrucine F (3) formed spontaneously from 1 in buffered water solutions. probably by oxidation at C-1 followed by water elimination

Publicerad i

Journal of Natural Products
2008, volym: 71, nummer: 8, sidor: 1455-1457
Utgivare: AMER CHEMICAL SOC

SLU författare

• Hedén, Su-Lin

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

• Schnürer, Johan

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

• Broberg, Anders

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Organisk kemi
Livsmedelsvetenskap
Mikrobiologi

Publikationens identifierare

• DOI: https://doi.org/10.1021/np800105e

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/18990