A von Willebrand factor-binding protein from Staphylococcus lugdunensis

Sammanfattning

In the present study, a phage display library covering the genome of Staphylococcus lugdunensis, was affinity-selected against von Willebrand factor (vWf). This led to the identification of a gene, vwbl, encoding a Putative cell surface protein of 2060 amino acids, denoted vWbl. The deduced protein has an overall organisation typical of staphylococcal cell Surface proteins, with an N-terminal signal peptide, and a C-terminal cell wall sorting signal. The vWf-binding part is located in repetitive domains and antibodies against vWbl or vWf can inhibit the binding. Southern blot analysis showed that vwbl was present in the 12 S. lugdunensis strains tested. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved

Publicerad i

FEMS Microbiology Letters
2004, volym: 234, nummer: 1, sidor: 155-161
Utgivare: ELSEVIER SCIENCE BV

SLU författare

• Bjerketorp, Joakim

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

• Frykberg, Lars

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

• Guss, Bengt

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Husdjursvetenskap
Veterinärmedicin

Publikationens identifierare

• DOI: https://doi.org/10.1016/j.femsle.2004.03.024

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/2816