Markers of Borna disease virus infection in cats with staggering disease

Sammanfattning

Borna disease virus (BDV) is a RNA-virus causing neurological disorders in a wide range of mammals. In cats, BDV infection may cause staggering disease. Presently, staggering disease is a tentative clinical diagnosis, only confirmed at necropsy. In this study, cats with staggering disease were investigated to study markers of BDV infection aiming for improvement of current diagnostics. Nineteen cats fulfilled the inclusion criteria based on neurological signs and pathological findings. In 17/19 cats, BDV infection markers (BDV-specific antibodies and/or BDV-RNA) were found, and antibodies in serum (13/16, 81%) were the most common marker. BDV-RNA was found in 11/19 cats (58%). In a reference population without neurological signs, 4/25 cats were seropositive (16%). The clinical history and neurological signs in combination with presence of BDV infection markers, where serology and rRT-PCR on blood can be helpful tools, improve the diagnostic accuracy in the living cat.

Publicerad i

Journal of Feline Medicine and Surgery
2012, volym: 14, nummer: 8, sidor: 573-582

SLU författare

• Johansson Wensman, Jonas

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Hultin Jäderlund, Karin

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Hagberg Gustavsson, Malin

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Hamlin, Helene

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Lilliehöök, Inger

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Belak, Sandor

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    
  • Sveriges Veterinärmedicinska Anstalt (SVA)

• Berg, Mikael

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Ström Holst, Bodil

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    
  • Sveriges Veterinärmedicinska Anstalt (SVA)

UKÄ forskningsämne

Klinisk vetenskap
Annan veterinärmedicin
Patobiologi

Publikationens identifierare

• DOI: https://doi.org/10.1177/1098612X12446638

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/57722