A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds

Abstract

Conclusions: A KCNJ10 mutation, previously associated with an autosomal recessive spinocerebellar ataxia in Jack Russell Terriers, Parson Russell Terriers, and Russell Terriers segregates in at least three more breeds descended from British hunting terriers. Ataxic members of two of these breeds, the Smooth-Haired Fox Terrier and the Toy Fox Terrier, were homozygous for the mutation, strengthening the likelihood that this genetic defect is indeed the causative mutation for the disease known as "hereditary ataxia" in Fox Terriers and "spinocerebellar ataxia with myokymia, seizures or both" in the Russell group of terriers.

Keywords

Dog; Spinocerebellar ataxia; Myokymia; Smooth-Haired Fox Terrier; Toy Fox Terrier; Jack Russell Terrier; Parson Russell Terrier; Russell Terrier; Tenterfield Terrier; KCNJ10

Published in

Acta Veterinaria Scandinavica
2015, volume: 57, number: 26

SLU Authors

• Rohdin, Cecilia

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    
  • Albano Animal Hospital

UKÄ Subject classification

Other Veterinary Science

Publication identifier

• DOI: https://doi.org/10.1186/s13028-015-0115-1

Permanent link to this page (URI)

https://res.slu.se/id/publ/70522