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Sammanfattning

Metabolic imbalance impairs fertility, because changes in concentrations of metabolites and hormones in the blood and follicular fluid create an unfavourable environment for early embryonic development. Insulin is a key metabolic hormone known for its effects on fertility: insulin concentrations are increased during energy balance disturbances in diabetes or metabolic syndrome. Still, insulin is frequently used at supraphysiological concentrations for embryo in vitro culture with unknown consequences for the developmental potential of the offspring. In the present study we investigated the effects of insulin exposure during in vitro bovine oocyte maturation on developmental rates, embryo quality and gene expression. Supplementation of the maturation media with insulin at 10 or 0.1 mu gmL(-1) decreased blastocyst rates compared with an insulin-free control (19.8 +/- 1.3% and 20.4 +/- 1.3% vs 23.8 +/- 1.3%, respectively; P

Nyckelord

dairy cow; embryo; metabolism; metabolic programming; metabolic syndrome; morphology; subfertility; transcriptome

Publicerad i

Reproduction, Fertility and Development
2017, volym: 29, nummer: 5, artikelnummer: 10.1071/RD15315

SLU författare

UKÄ forskningsämne

Klinisk vetenskap
Genetik och förädling inom lantbruksvetenskap
Husdjursvetenskap

Publikationens identifierare

  • DOI: https://doi.org/10.1071/RD15315

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/79274