Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs

Abstract

Chronic kidney disease (CKD) is clinically important in canine medicine. Current diagnostic tools lack sensitivity for detection of subclinical CKD. The aim of the present study was to evaluate urinary peptidome analysis for diagnosis of CKD in dogs. Capillary electrophoresis coupled to mass spectrometry analysis demonstrated presence of approximately 5400 peptides in dog urine. Comparison of urinary peptide abundance of dogs with and without CKD led to the identification of 133 differentially excreted peptides (adjusted P for each peptide

Keywords

Canine; Renal; Capillary electrophoresis; Proteomics

Published in

Veterinary Journal
2019, volume: 249, pages: 73-79

SLU Authors

• Pelander, Lena

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Häggström, Jens

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Clinical Science

Publication identifier

• DOI: https://doi.org/10.1016/j.tvjl.2019.05.010

Permanent link to this page (URI)

https://res.slu.se/id/publ/100587