Urinary peptidome analyses for the diagnosis of chronic kidney disease in dogs

Sammanfattning

Chronic kidney disease (CKD) is clinically important in canine medicine. Current diagnostic tools lack sensitivity for detection of subclinical CKD. The aim of the present study was to evaluate urinary peptidome analysis for diagnosis of CKD in dogs. Capillary electrophoresis coupled to mass spectrometry analysis demonstrated presence of approximately 5400 peptides in dog urine. Comparison of urinary peptide abundance of dogs with and without CKD led to the identification of 133 differentially excreted peptides (adjusted P for each peptide

Nyckelord

Canine; Renal; Capillary electrophoresis; Proteomics

Publicerad i

Veterinary Journal
2019, volym: 249, sidor: 73-79

SLU författare

• Pelander, Lena

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Häggström, Jens

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Klinisk vetenskap

Publikationens identifierare

• DOI: https://doi.org/10.1016/j.tvjl.2019.05.010

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/100587