Effect of novel metabotropic glutamate receptor 5 antagonist on gastroesophageal reflux in dogs during anaesthesia

Abstract

Objectives Gastroesophageal reflux during anaesthesia is a common event occurring in dogs with the potential to cause oesophageal injury and aspiration pneumonia. The objective of the current study was to evaluate the effect of the novel metabotropic glutamate receptor 5 antagonist TT001 on gastroesophageal reflux during anaesthesia in dogs using two different protocols. Materials and Methods One hundred and nineteen client-owned dogs were included and randomly assigned to receive test-drug containing either active TT001 (n = 58) or placebo vehicle (n = 61). In protocol 1 (n = 77), test-drug was administered shortly before induction and in protocol 2 (n = 42) test-drug was administered 15 minutes before standardised pre anaesthetic drugs. Gastroesophageal reflux (pH

Published in

Journal of Small Animal Practice
2025
Publisher: WILEY

SLU Authors

• Höglund, Odd

  • Department of Clinical Sciences, Swedish University of Agricultural Sciences
    

• Ekstrand, Carl

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Flöhr, Adam

  • Department of Biosystems and Technology, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Clinical Science

Publication identifier

• DOI: https://doi.org/10.1111/jsap.70053

Permanent link to this page (URI)

https://res.slu.se/id/publ/144880