Effect of novel metabotropic glutamate receptor 5 antagonist on gastroesophageal reflux in dogs during anaesthesia

Sammanfattning

Objectives Gastroesophageal reflux during anaesthesia is a common event occurring in dogs with the potential to cause oesophageal injury and aspiration pneumonia. The objective of the current study was to evaluate the effect of the novel metabotropic glutamate receptor 5 antagonist TT001 on gastroesophageal reflux during anaesthesia in dogs using two different protocols. Materials and Methods One hundred and nineteen client-owned dogs were included and randomly assigned to receive test-drug containing either active TT001 (n = 58) or placebo vehicle (n = 61). In protocol 1 (n = 77), test-drug was administered shortly before induction and in protocol 2 (n = 42) test-drug was administered 15 minutes before standardised pre anaesthetic drugs. Gastroesophageal reflux (pH

Publicerad i

Journal of Small Animal Practice
2025
Utgivare: WILEY

SLU författare

• Höglund, Odd

  • Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
    

• Ekstrand, Carl

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Flöhr, Adam

  • Institutionen för biosystem och teknologi, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Klinisk vetenskap

Publikationens identifierare

• DOI: https://doi.org/10.1111/jsap.70053

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/144880