Pelander, Lena
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Abstract
Background: Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required.Objective: To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection of decreased GFR in clinically stable dogs, with or without chronic kidney disease (CKD).Animals: Ninety-seven client-owned dogs: 67 dogs with a diagnosis or suspicion of CKD and 30 healthy dogs were prospectively included.Methods: Prospective diagnostic accuracy study. All dogs underwent physical examination, systemic arterial blood pressure measurement, urinalysis, hematology and blood biochemistry analysis, cardiac and urinary ultrasound examinations, and scintigraphy for estimation of glomerular filtration rate (mGFR). Frozen serum was used for batch analysis of SDMA and cystatin C.Results: The area under the curve of creatinine, SDMA, and cystatin C for detection of an mGFR
Keywords
azotemia; biomarker; canine; CKD; renal
Published in
Journal of Veterinary Internal Medicine
2019, volume: 33, number: 2, pages: 630-639
Publisher: WILEY
SLU Authors
Häggström, Jens
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
Ljungvall, Ingrid
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
- Department of Clinical Sciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Clinical Science
Publication identifier
- DOI: https://doi.org/10.1111/jvim.15445
Permanent link to this page (URI)
https://res.slu.se/id/publ/99793