Pelander, Lena
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Background: Early detection of decreased glomerular filtration rate (GFR) in dogs is challenging. Current methods are insensitive and new biomarkers are required.Objective: To compare overall diagnostic performance of serum symmetric dimethylarginine (SDMA) and serum cystatin C to serum creatinine, for detection of decreased GFR in clinically stable dogs, with or without chronic kidney disease (CKD).Animals: Ninety-seven client-owned dogs: 67 dogs with a diagnosis or suspicion of CKD and 30 healthy dogs were prospectively included.Methods: Prospective diagnostic accuracy study. All dogs underwent physical examination, systemic arterial blood pressure measurement, urinalysis, hematology and blood biochemistry analysis, cardiac and urinary ultrasound examinations, and scintigraphy for estimation of glomerular filtration rate (mGFR). Frozen serum was used for batch analysis of SDMA and cystatin C.Results: The area under the curve of creatinine, SDMA, and cystatin C for detection of an mGFR
Nyckelord
azotemia; biomarker; canine; CKD; renal
Publicerad i
Journal of Veterinary Internal Medicine
2019, volym: 33, nummer: 2, sidor: 630-639
Utgivare: WILEY
SLU författare
Häggström, Jens
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
Ljungvall, Ingrid
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
- Institutionen för kliniska vetenskaper, Sveriges lantbruksuniversitet
UKÄ forskningsämne
Klinisk vetenskap
Publikationens identifierare
- DOI: https://doi.org/10.1111/jvim.15445
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/99793